Overview of the Yeast Example

The microarray data for this example is from DeRisi, JL, Iyer, VR, and Brown, PO.; "Exploring the metabolic and genetic control of gene expression on a genomic scale"; Science, 1997, Oct 24;278(5338):680-6, PMID: 9381177.

The authors used DNA microarrays to study temporal gene expression of almost all genes in Saccharomyces cerevisiae during the metabolic shift from fermentation to respiration. Expression levels were measured at seven time points during the diauxic shift. The full data set can be downloaded from the Gene Expression Omnibus Web site at

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE28


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