LOCUS NP_000213 976 aa linear PRI 20-DEC-2003 DEFINITION v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog precursor [Homo sapiens]. ACCESSION NP_000213 VERSION NP_000213.1 GI:4557695 DBSOURCE REFSEQ: accession NM_000222.1 KEYWORDS . SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 976) AUTHORS Wardelmann,E., Losen,I., Hans,V., Neidt,I., Speidel,N., Bierhoff,E., Heinicke,T., Pietsch,T., Buttner,R. and Merkelbach-Bruse,S. TITLE Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors JOURNAL Int. J. Cancer 106 (6), 887-895 (2003) PUBMED 12918066 REMARK GeneRIF: Mutations and deletions in c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors REFERENCE 2 (residues 1 to 976) AUTHORS Lennartsson,J., Wernstedt,C., Engstrom,U., Hellman,U. and Ronnstrand,L. TITLE Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk JOURNAL Exp. Cell Res. 288 (1), 110-118 (2003) PUBMED 12878163 REMARK GeneRIF: c-Src phosphorylates the receptor KIT, thereby creating docking sites for SH2 domain containing proteins, leading to recruitment of Crk to the receptor. REFERENCE 3 (residues 1 to 976) AUTHORS Sakuma,Y., Sakurai,S., Oguni,S., Hironaka,M. and Saito,K. TITLE Alterations of the c-kit gene in testicular germ cell tumors JOURNAL Cancer Sci 94 (6), 486-491 (2003) PUBMED 12824871 REMARK GeneRIF: Mutations of the c-kit gene is associated with testicular germ cell tumors REFERENCE 4 (residues 1 to 976) AUTHORS Yasuoka,R., Sakakura,C., Shimomura,K., Fujita,Y., Nakanishi,M., Aragane,H., Hagiwara,A., Bamba,M., Abe,T. and Yamagishi,H. TITLE Mutations in exon 11 of the c-kit gene in a myogenic tumor and a neurogenic tumor as well as in gastrointestinal stromal tumors. Utility of c-kit mutation as a prognostic biomarker for gastrointestinal mesenchymal tumor JOURNAL Dig Surg 20 (3), 183-191 (2003) PUBMED 12759497 REMARK GeneRIF: gain-of-function mutation in exon 11 of the c-kit gene is an important prognostic factor for gastrointestinal mesenchymal tumors, including myogenic and neurogenic tumors as well as GISTs REFERENCE 5 (residues 1 to 976) AUTHORS Araki,K., Ishii,G., Yokose,T., Nagai,K., Funai,K., Kodama,K., Nishiwaki,Y. and Ochiai,A. TITLE Frequent overexpression of the c-kit protein in large cell neuroendocrine carcinoma of the lung JOURNAL Lung Cancer 40 (2), 173-180 (2003) PUBMED 12711118 REMARK GeneRIF: overexpression of the c-kit protein is associated with large cell neuroendocrine carcinoma of the lung REFERENCE 6 (residues 1 to 976) AUTHORS Sotlar,K., Escribano,L., Landt,O., Mohrle,S., Herrero,S., Torrelo,A., Lass,U., Horny,H.P. and Bultmann,B. TITLE One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes JOURNAL Am. J. Pathol. 162 (3), 737-746 (2003) PUBMED 12598308 REMARK GeneRIF: Point mutation may be associated with urticaria pigmentosa in children. REFERENCE 7 (residues 1 to 976) AUTHORS Voytyuk,O., Lennartsson,J., Mogi,A., Caruana,G., Courtneidge,S., Ashman,L.K. and Ronnstrand,L. TITLE Src family kinases are involved in the differential signaling from two splice forms of c-Kit JOURNAL J. Biol. Chem. 278 (11), 9159-9166 (2003) PUBMED 12511554 REMARK GeneRIF: KIT isoforms have remarkable differences in their signaling capabilities REFERENCE 8 (residues 1 to 976) AUTHORS Cairoli,R., Grillo,G., Beghini,A., Tedeschi,A., Ripamonti,C.B., Larizza,L. and Morra,E. TITLE C-Kit point mutations in core binding factor leukemias: correlation with white blood cell count and the white blood cell index JOURNAL Leukemia 17 (2), 471-472 (2003) PUBMED 12592353 REMARK GeneRIF: Point mutations in c-Kit in core binding factor leukemias correlate with white blood cell count and the white blood cell index REFERENCE 9 (residues 1 to 976) AUTHORS Yamazaki,K., Sakamoto,M., Ohta,T., Kanai,Y., Ohki,M. and Hirohashi,S. TITLE Overexpression of KIT in chromophobe renal cell carcinoma JOURNAL Oncogene 22 (6), 847-852 (2003) PUBMED 12584564 REMARK GeneRIF: KIT could be a useful marker for chromophobe renal cell carcinomas REFERENCE 10 (residues 1 to 976) AUTHORS Kinoshita,K., Isozaki,K., Hirota,S., Nishida,T., Chen,H., Nakahara,M., Nagasawa,Y., Ohashi,A., Shinomura,Y., Kitamura,Y. and Matsuzawa,Y. TITLE c-kit gene mutation at exon 17 or 13 is very rare in sporadic gastrointestinal stromal tumors JOURNAL J. Gastroenterol. Hepatol. 18 (2), 147-151 (2003) PUBMED 12542597 REFERENCE 11 (residues 1 to 976) AUTHORS Heinrich,M.C., Corless,C.L., Duensing,A., McGreevey,L., Chen,C.J., Joseph,N., Singer,S., Griffith,D.J., Haley,A., Town,A., Demetri,G.D., Fletcher,C.D. and Fletcher,J.A. TITLE PDGFRA activating mutations in gastrointestinal stromal tumors JOURNAL Science 299 (5607), 708-710 (2003) PUBMED 12522257 REMARK GeneRIF: KIT and PDGFRA mutations appear to be alternative and mutually exclusive oncogenic mechanisms in gastrointestinal stromal tumors REFERENCE 12 (residues 1 to 976) AUTHORS Wojda,U., Leigh,K.R., Njoroge,J.M., Jackson,K.A., Natarajan,B., Stitely,M. and Miller,J.L. TITLE Fetal hemoglobin modulation during human erythropoiesis: stem cell factor has 'late' effects related to the expression pattern of CD117 JOURNAL Blood 101 (2), 492-497 (2003) PUBMED 12393703 REMARK GeneRIF: stem cell factor has 'late' effects on fetal hemoglobin modulation during erythropoiesis, related to the expression pattern of CD117. REFERENCE 13 (residues 1 to 976) AUTHORS Vanderwinden,J.M., Rumessen,J.J., de Kerchove d'Exaerde,A. Jr., Gillard,K., Panthier,J.J., de Laet,M.H. and Schiffmann,S.N. TITLE Kit-negative fibroblast-like cells expressing SK3, a Ca2+-activated K+ channel, in the gut musculature in health and disease JOURNAL Cell Tissue Res. 310 (3), 349-358 (2002) PUBMED 12457234 REMARK GeneRIF: Fibroblat-like cells lacking this protein express SK3 in smooth gut muscle in health and dissease. REFERENCE 14 (residues 1 to 976) AUTHORS Esposito,I., Kleeff,J., Bischoff,S.C., Fischer,L., Collecchi,P., Iorio,M., Bevilacqua,G., Buchler,M.W. and Friess,H. TITLE The stem cell factor-c-kit system and mast cells in human pancreatic cancer JOURNAL Lab. Invest. 82 (11), 1481-1492 (2002) PUBMED 12429808 REMARK GeneRIF: the SCF-c-kit system, possibly with the contribution of mast cells, may have a growth-regulating role in the normal pancreas, which is altered during malignant transformation. REFERENCE 15 (residues 1 to 976) AUTHORS Przygodzki,R.M., Hubbs,A.E., Zhao,F.Q. and O'Leary,T.J. TITLE Primary mediastinal seminomas: evidence of single and multiple KIT mutations JOURNAL Lab. Invest. 82 (10), 1369-1375 (2002) PUBMED 12379771 REMARK GeneRIF: findings demonstrate a unique KIT sequence and expression pattern among mediastinal seminomas; KIT sequencing may assist in differentiating primary from metastatic MS REFERENCE 16 (residues 1 to 976) AUTHORS Ma,D., Liu,X., Cai,Z. and Xie,Q. TITLE Expression and mutation of c-kit gene in gastrointestinal stromal tumor JOURNAL Zhonghua Zhong Liu Za Zhi 24 (5), 461-464 (2002) PUBMED 12485499 REMARK GeneRIF: c-kit gene mutation may play a significant role in the pathogenesis of GIST and also may be a prognostic marker. REFERENCE 17 (residues 1 to 976) AUTHORS Syrris,P., Heathcote,K., Carrozzo,R., Devriendt,K., Elcioglu,N., Garrett,C., McEntagart,M. and Carter,N.D. TITLE Human piebaldism: six novel mutations of the proto-oncogene KIT JOURNAL Hum. Mutat. 20 (3), 234 (2002) PUBMED 12204004 REMARK GeneRIF: Mutations were not detected in over 100 normal individuals and are likely to be the cause of piebaldism in our subjects. REFERENCE 18 (residues 1 to 976) AUTHORS Hotfilder,M., Lanvers,C., Jurgens,H., Boos,J. and Vormoor,J. TITLE c-KIT-expressing Ewing tumour cells are insensitive to imatinib mesylate (STI571) JOURNAL Cancer Chemother Pharmacol 50 (2), 167-169 (2002) PUBMED 12172985 REMARK GeneRIF: c-Kit-expressing Ewing tumor cells are resistant to imatinib mesylate. REFERENCE 19 (residues 1 to 976) AUTHORS Moses,A.V., Jarvis,M.A., Raggo,C., Bell,Y.C., Ruhl,R., Luukkonen,B.G., Griffith,D.J., Wait,C.L., Druker,B.J., Heinrich,M.C., Nelson,J.A. and Fruh,K. TITLE Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells JOURNAL J. Virol. 76 (16), 8383-8399 (2002) PUBMED 12134042 REMARK GeneRIF: essential role for c-Kit in KS tumorigenesis REFERENCE 20 (residues 1 to 976) AUTHORS Beghini,A., Magnani,I., Ripamonti,C.B. and Larizza,L. TITLE Amplification of a novel c-Kit activating mutation Asn(822)-Lys in the Kasumi-1 cell line: a t(8;21)-Kit mutant model for acute myeloid leukemia JOURNAL Hematol. J. 3 (3), 157-163 (2002) PUBMED 12111653 REMARK GeneRIF: Asn(822)-Lys mutation affecting a highly conserved codon within the tyrosine kinase activation loop leading to constitutive ligand-independent activation of the KIT receptor was identified in the Kasumi-1 cell REFERENCE 21 (residues 1 to 976) AUTHORS Yavuz,A.S., Lipsky,P.E., Yavuz,S., Metcalfe,D.D. and Akin,C. TITLE Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene JOURNAL Blood 100 (2), 661-665 (2002) PUBMED 12091362 REMARK GeneRIF: Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene. REFERENCE 22 (residues 1 to 976) AUTHORS Scolnik,M.P., Morilla,R., de Bracco,M.M., Catovsky,D. and Matutes,E. TITLE CD34 and CD117 are overexpressed in AML and may be valuable to detect minimal residual disease JOURNAL Leuk. Res. 26 (7), 615-619 (2002) PUBMED 12008077 REMARK GeneRIF: We have shown for the 1st time that CD117 is expressed at a much higher level in AML myeloblasts than in normal myeloid precursors. REFERENCE 23 (residues 1 to 976) AUTHORS Liu,H. and Verfaillie,C.M. TITLE Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells JOURNAL Exp. Hematol. 30 (6), 582-589 (2002) PUBMED 12063025 REFERENCE 24 (residues 1 to 976) AUTHORS Sandberg,A.A. and Bridge,J.A. TITLE Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. gastrointestinal stromal tumors JOURNAL Cancer Genet. Cytogenet. 135 (1), 1-22 (2002) PUBMED 12072198 REMARK GeneRIF: all classes of interstitial cells of Cajal express CD117, thus it serves as a marker for gastrointestinal stromal tumors (GIST) derived from these cells; mutations in CD117 or aberrations of chromosome 4 are often found in GIST - review REFERENCE 25 (residues 1 to 976) AUTHORS Valent,P., Ghannadan,M., Hauswirth,A.W., Schernthaner,G.H., Sperr,W.R. and Arock,M. TITLE Signal transduction-associated and cell activation-linked antigens expressed in human mast cells JOURNAL Int. J. Hematol. 75 (4), 357-362 (2002) PUBMED 12041664 REMARK GeneRIF: REVIEW: Signal transduction though the KIT pathway in mast cells and involvement in MC activation and mediator release. REFERENCE 26 (residues 1 to 976) AUTHORS Gupta,R., Bain,B.J. and Knight,C.L. TITLE Cytogenetic and molecular genetic abnormalities in systemic mastocytosis JOURNAL Acta Haematol. 107 (2), 123-128 (2002) PUBMED 11919394 REMARK GeneRIF: role of c-KIT mutations in the biology of mast cell malignancies REFERENCE 27 (residues 1 to 976) AUTHORS Liang,X., Wisniewski,D., Strife,A., Shivakrupa, Clarkson,B. and Resh,M.D. TITLE Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling JOURNAL J. Biol. Chem. 277 (16), 13732-13738 (2002) PUBMED 11825908 REMARK GeneRIF: Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. REFERENCE 28 (residues 1 to 976) AUTHORS Ma,Y., Zeng,S., Metcalfe,D.D., Akin,C., Dimitrijevic,S., Butterfield,J.H., McMahon,G. and Longley,B.J. TITLE The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations JOURNAL Blood 99 (5), 1741-1744 (2002) PUBMED 11861291 REMARK GeneRIF: Mutations of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human mastocytosis (SAHM) and with human gastrointestinal stromal tumors. REFERENCE 29 (residues 1 to 976) AUTHORS Andersson,J., Sjogren,H., Meis-Kindblom,J.M., Stenman,G., Aman,P. and Kindblom,L.G. TITLE The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors JOURNAL Am. J. Pathol. 160 (1), 15-22 (2002) PUBMED 11786393 REMARK GeneRIF: The complexity of KIT gene mutations and chromosome rearrangements and their clinical correlation in gastrointestinal stromal (pacemaker cell) tumors. REFERENCE 30 (residues 1 to 976) AUTHORS Acebo,E., Val-Bernal,J.F. and Gomez-Roman,J.J. TITLE Thrombomodulin, calretinin and c-kit (CD117) expression in cardiac myxoma JOURNAL Histol. Histopathol. 16 (4), 1031-1036 (2001) PUBMED 11642722 REMARK GeneRIF: a tumor marker for cardiac myxoma REFERENCE 31 (residues 1 to 976) AUTHORS Longley,B.J. Jr., Metcalfe,D.D., Tharp,M., Wang,X., Tyrrell,L., Lu,S.Z., Heitjan,D. and Ma,Y. TITLE Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis JOURNAL Proc. Natl. Acad. Sci. U.S.A. 96 (4), 1609-1614 (1999) PUBMED 9990072 REFERENCE 32 (residues 1 to 976) AUTHORS Hirota,S., Isozaki,K., Moriyama,Y., Hashimoto,K., Nishida,T., Ishiguro,S., Kawano,K., Hanada,M., Kurata,A., Takeda,M., Muhammad Tunio,G., Matsuzawa,Y., Kanakura,Y., Shinomura,Y. and Kitamura,Y. TITLE Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors JOURNAL Science 279 (5350), 577-580 (1998) PUBMED 9438854 REFERENCE 33 (residues 1 to 976) AUTHORS Andre,C., Hampe,A., Lachaume,P., Martin,E., Wang,X.P., Manus,V., Hu,W.X. and Galibert,F. TITLE Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes JOURNAL Genomics 39 (2), 216-226 (1997) PUBMED 9027509 REFERENCE 34 (residues 1 to 976) AUTHORS Zhu,W.M., Dong,W.F. and Minden,M. TITLE Alternate splicing creates two forms of the human kit protein JOURNAL Leuk. Lymphoma 12 (5-6), 441-447 (1994) PUBMED 7514064 REFERENCE 35 (residues 1 to 976) AUTHORS Toyota,M., Hinoda,Y., Itoh,F., Takaoka,A., Imai,K. and Yachi,A. TITLE Complementary DNA cloning and characterization of truncated form of c-kit in human colon carcinoma cells JOURNAL Cancer Res. 54 (1), 272-275 (1994) PUBMED 7505199 REFERENCE 36 (residues 1 to 976) AUTHORS Yamamoto,K., Tojo,A., Aoki,N. and Shibuya,M. TITLE Characterization of the promoter region of the human c-kit proto-oncogene JOURNAL Jpn. J. Cancer Res. 84 (11), 1136-1144 (1993) PUBMED 7506248 REFERENCE 37 (residues 1 to 976) AUTHORS Giebel,L.B., Strunk,K.M., Holmes,S.A. and Spritz,R.A. TITLE Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene JOURNAL Oncogene 7 (11), 2207-2217 (1992) PUBMED 1279499 REFERENCE 38 (residues 1 to 976) AUTHORS Andre,C., Martin,E., Cornu,F., Hu,W.X., Wang,X.P. and Galibert,F. TITLE Genomic organization of the human c-kit gene: evolution of the receptor tyrosine kinase subclass III JOURNAL Oncogene 7 (4), 685-691 (1992) PUBMED 1373482 REFERENCE 39 (residues 1 to 976) AUTHORS Giebel,L.B. and Spritz,R.A. TITLE Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88 (19), 8696-8699 (1991) PUBMED 1717985 REFERENCE 40 (residues 1 to 976) AUTHORS Yarden,Y., Kuang,W.J., Yang-Feng,T., Coussens,L., Munemitsu,S., Dull,T.J., Chen,E., Schlessinger,J., Francke,U. and Ullrich,A. TITLE Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand JOURNAL EMBO J. 6 (11), 3341-3351 (1987) PUBMED 2448137 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X06182.1. Summary: KIT encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. FEATURES Location/Qualifiers source 1..976 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="4" /map="4q11-q12" Protein 1..976 /product="v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog precursor" /EC_number="2.7.1.112" sig_peptide 1..22 mat_peptide 23..976 /product="v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog" Region 222..307 /region_name="Immunoglobulin like" /note="IG_like" /db_xref="CDD:5322" Region 262..959 /region_name="Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases [Signal transduction mechanisms]" /note="KOG0200" /db_xref="CDD:17996" variation 541 /replace="L" /replace="M" /replace="V" /db_xref="dbSNP:3822214" Region 581..>694 /region_name="Tyrosine kinase, catalytic domain" /note="TyrKc" /db_xref="CDD:5392" Region <771..926 /region_name="Tyrosine kinase, catalytic domain" /note="TyrKc" /db_xref="CDD:5392" CDS 1..976 /gene="KIT" /coded_by="NM_000222.1:22..2952" /note="go_component: integral to membrane [goid 0016021] [evidence IEA]; go_function: protein-tyrosine kinase activity [goid 0004713] [evidence E] [pmid 1717985]; go_function: transmembrane receptor protein tyrosine kinase activity [goid 0004714] [evidence NR]; go_function: receptor signaling protein tyrosine kinase activity [goid 0004716] [evidence TAS] [pmid 9438854]; go_function: ATP binding [goid 0005524] [evidence IEA]; go_function: receptor activity [goid 0004872] [evidence IEA]; go_function: transferase activity [goid 0016740] [evidence IEA]; go_function: vascular endothelial growth factor receptor activity [goid 0005021] [evidence IEA]; go_process: oncogenesis [goid 0007048] [evidence NR]; go_process: signal transduction [goid 0007165] [evidence TAS] [pmid 9990072]; go_process: protein amino acid dephosphorylation [goid 0006470] [evidence NR]; go_process: transmembrane receptor protein tyrosine kinase signaling pathway [goid 0007169] [evidence IEA]; go_process: cell growth and/or maintenance [goid 0008151] [evidence IEA]; go_process: protein amino acid phosphorylation [goid 0006468] [evidence IEA]" /db_xref="GeneID:3815" /db_xref="LocusID:3815" /db_xref="MIM:164920" ORIGIN 1 mrgargawdf lcvlllllrv qtgssqpsvs pgepsppsih pgksdlivrv gdeirllctd 61 pgfvkwtfei ldetnenkqn ewitekaeat ntgkytctnk hglsnsiyvf vrdpaklflv 121 drslygkedn dtlvrcpltd pevtnyslkg cqgkplpkdl rfipdpkagi miksvkrayh 181 rlclhcsvdq egksvlsekf ilkvrpafka vpvvsvskas yllregeeft vtctikdvss 241 svystwkren sqtklqekyn swhhgdfnye rqatltissa rvndsgvfmc yanntfgsan 301 vtttlevvdk gfinifpmin ttvfvndgen vdliveyeaf pkpehqqwiy mnrtftdkwe 361 dypksenesn iryvselhlt rlkgteggty tflvsnsdvn aaiafnvyvn tkpeiltydr 421 lvngmlqcva agfpeptidw yfcpgteqrc sasvlpvdvq tlnssgppfg klvvqssids 481 safkhngtve ckayndvgkt sayfnfafkg nnkeqihpht lftplligfv ivagmmciiv 541 miltykylqk pmyevqwkvv eeingnnyvy idptqlpydh kwefprnrls fgktlgagaf 601 gkvveatayg liksdaamtv avkmlkpsah lterealmse lkvlsylgnh mnivnllgac 661 tiggptlvit eyccygdlln flrrkrdsfi cskqedhaea alyknllhsk esscsdstne 721 ymdmkpgvsy vvptkadkrr svrigsyier dvtpaimedd elaldledll sfsyqvakgm 781 aflaskncih rdlaarnill thgritkicd fglardiknd snyvvkgnar lpvkwmapes 841 ifncvytfes dvwsygiflw elfslgsspy pgmpvdskfy kmikegfrml spehapaemy 901 dimktcwdad plkrptfkqi vqliekqise stnhiysnla ncspnrqkpv vdhsvrinsv 961 gstasssqpl lvhddv //