BLASTP 2.2.6 [Apr-09-2003]

Query= PDGF alpha precursor (NP_006197)
         (1089 letters)

Database: PDB protein database 
           45,671 sequences; 10,828,398 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

pdb|1PKG|A Chain A, Structure Of A C-Kit Kinase Product Complex ...   245   5e-66
pdb|1VR2|A Chain A, Human Vascular Endothelial Growth Factor Rec...   216   2e-57
pdb|1FGI|A Chain A, Crystal Structure Of The Tyrosine Kinase Dom...   197   1e-51
pdb|1GJO|A Chain A, The Fgfr2 Tyrosine Kinase Domain                  194   1e-50
pdb|1FVR|A Chain A, Tie2 Kinase Domain >gi|15988251|pdb|1FVR|B C...   166   4e-42
pdb|1QCF|A Chain A, Crystal Structure Of Hck In Complex With A S...   150   1e-37
pdb|1QPE|A Chain A, Structural Analysis Of The Lymphocyte-Specif...   144   9e-36
pdb|1QPD|A Chain A, Structural Analysis Of The Lymphocyte-Specif...   144   9e-36
pdb|3LCK|  The Kinase Domain Of Human Lymphocyte Kinase (Lck), A...   143   2e-35
pdb|1OPL|A Chain A, Structural Basis For The Auto-Inhibition Of ...   142   4e-35
pdb|1FMK|  Crystal Structure Of Human Tyrosine-Protein Kinase C-...   140   1e-34
pdb|1KSW|A Chain A, Structure Of Human C-Src Tyrosine Kinase (Th...   140   2e-34
pdb|1AD5|A Chain A, Src Family Kinase Hck-Amp-Pnp Complex >gi|21...   140   2e-34
pdb|1BYG|A Chain A, Kinase Domain Of Human C-Terminal Src Kinase...   140   2e-34
pdb|1I44|A Chain A, Crystallographic Studies Of An Activation Lo...   139   3e-34
pdb|1IRK|  Insulin Receptor (Tyrosine Kinase Domain) Mutant With...   139   4e-34
pdb|1M7N|A Chain A, Crystal Structure Of Unactivated Apo Insulin...   139   5e-34
pdb|1JQH|A Chain A, Igf-1 Receptor Kinase Domain >gi|20663952|pd...   139   5e-34
pdb|1P4O|A Chain A, Structure Of Apo Unactivated Igf-1r Kinase D...   139   5e-34
pdb|1P14|A Chain A, Crystal Structure Of A Catalytic-Loop Mutant...   137   2e-33
pdb|1IR3|A Chain A, Phosphorylated Insulin Receptor Tyrosine Kin...   136   2e-33
pdb|1K3A|A Chain A, Structure Of The Insulin-Like Growth Factor ...   134   9e-33
pdb|1M14|A Chain A, Tyrosine Kinase Domain From Epidermal Growth...   132   4e-32
pdb|1K2P|A Chain A, Crystal Structure Of Bruton's Tyrosine Kinas...   125   4e-30
pdb|1PME|  Structure Of Penta Mutant Human Erk2 Map Kinase Compl...    69   6e-13
pdb|1JOW|B Chain B, Crystal Structure Of A Complex Of Human Cdk6...    64   1e-11
pdb|1BI8|A Chain A, Mechanism Of G1 Cyclin Dependent Kinase Inhi...    64   1e-11
pdb|1F3M|C Chain C, Crystal Structure Of Human SerineTHREONINE K...    62   6e-11

ALIGNMENTS
>pdb|1PKG|A Chain A, Structure Of A C-Kit Kinase Product Complex
 pdb|1PKG|B Chain B, Structure Of A C-Kit Kinase Product Complex
          Length = 329

 Score =  245 bits (625), Expect = 5e-66
 Identities = 113/183 (61%), Positives = 143/183 (78%)

Query: 769 KKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ 828
           K+ S + S+    + +D+   L L DLLSF+YQVA+GM FLASKNC+HRDLAARN+LL  
Sbjct: 137 KRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH 196

Query: 829 GKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEI 888
           G+I KICDFGLARDI +DSNYV KG+  LPVKWMAPESIF+ +YT  SDVWSYGI LWE+
Sbjct: 197 GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWEL 256

Query: 889 FSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE 948
           FSLG +PYPGM VDS FY  IK G+RM  P+HA +E+Y+IM  CW+++P KRP+F  + +
Sbjct: 257 FSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQ 316

Query: 949 IVE 951
           ++E
Sbjct: 317 LIE 319



 Score =  195 bits (496), Expect = 4e-51
 Identities = 94/172 (54%), Positives = 124/172 (72%), Gaps = 2/172 (1%)

Query: 551 QKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEG 610
           QKP YE++W+V+E I+  G+  + +DP QLPYD +WEFPR+ L  G+ LG+GAFGKVVE 
Sbjct: 1   QKPMYEVQWKVVEEIN--GNNXVXIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEA 58

Query: 611 TAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPI 670
           TAYGL +S   M VAVKMLKP+A  +E++ALMSELK++++LG H+NIVNLLGACT  GP 
Sbjct: 59  TAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPT 118

Query: 671 YIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVI 722
            +ITEYC YGDL+N+L + RDSF+         E D   L+  D  + SY +
Sbjct: 119 LVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQV 170


>pdb|1VR2|A Chain A, Human Vascular Endothelial Growth Factor Receptor 2 (Kdr)
           Kinase Domain
          Length = 316

 Score =  216 bits (550), Expect = 2e-57
 Identities = 97/165 (58%), Positives = 127/165 (76%)

Query: 790 LTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNY 849
           LTL  L+ +++QVA+GMEFLAS+ C+HRDLAARN+LL++  +VKICDFGLARDI  D + 
Sbjct: 145 LTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDX 204

Query: 850 VSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKI 909
           V KG   LP+KWMAPE+IFD +YT  SDVWS+G+LLWEIFSLG +PYPG+ +D  F  ++
Sbjct: 205 VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL 264

Query: 910 KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
           K G RM  PD+ T E+Y+ M+ CW+ EP +RP+F  L E + NLL
Sbjct: 265 KEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLL 309



 Score =  136 bits (342), Expect = 3e-33
 Identities = 67/120 (55%), Positives = 88/120 (73%), Gaps = 2/120 (1%)

Query: 579 QLPYD-SRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSE 637
           +LPYD S+WEFPRD L LG+ LG GAFG+V+E  A+G+ ++     VAVKMLK  A  SE
Sbjct: 14  RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE 73

Query: 638 KQALMSELKIMTHLGPHLNIVNLLGACTK-SGPIYIITEYCFYGDLVNYLHKNRDSFLSH 696
            +ALMSELKI+ H+G HLN+VNLLGACTK  GP+ +I E+C +G+L  YL   R+ F+ +
Sbjct: 74  HRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPY 133


>pdb|1FGI|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of
           Fibroblast Growth Factor Receptor 1 In Complex With
           Su5402 Inhibitor
 pdb|1FGI|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of
           Fibroblast Growth Factor Receptor 1 In Complex With
           Su5402 Inhibitor
 pdb|1AGW|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of
           Fibroblast Growth Factor Receptor 1 In Complex With
           Su4984 Inhibitor
 pdb|1AGW|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of
           Fibroblast Growth Factor Receptor 1 In Complex With
           Su4984 Inhibitor
 pdb|2FGI|A Chain A, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf
           Receptor 1 In Complex With Inhibitor Pd173074
 pdb|2FGI|B Chain B, Crystal Structure Of The Tyrosine Kinase Domain Of Fgf
           Receptor 1 In Complex With Inhibitor Pd173074
          Length = 310

 Score =  197 bits (500), Expect = 1e-51
 Identities = 93/172 (54%), Positives = 126/172 (73%), Gaps = 1/172 (0%)

Query: 783 SDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARD 842
           S +  E L+  DL+S  YQVARGME+LASK C+HRDLAARNVL+ +  ++KI DFGLARD
Sbjct: 133 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 192

Query: 843 IMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVD 902
           I H   Y    +  LPVKWMAPE++FD +YT  SDVWS+G+LLWEIF+LGG+PYPG+ V+
Sbjct: 193 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 252

Query: 903 STFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
             F   +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ ++
Sbjct: 253 ELF-KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 303



 Score =  125 bits (314), Expect = 5e-30
 Identities = 68/141 (48%), Positives = 87/141 (61%), Gaps = 8/141 (5%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPT 632
           V   +LP D RWE PRD LVLG+ LG GAFG+VV   A GL + +P  V KVAVKMLK  
Sbjct: 5   VSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSD 64

Query: 633 ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDS 692
           A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL   R  
Sbjct: 65  ATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP 124

Query: 693 FL------SHHPEKPKKELDI 707
            L      SH+PE+     D+
Sbjct: 125 GLEYSYNPSHNPEEQLSSKDL 145


>pdb|1GJO|A Chain A, The Fgfr2 Tyrosine Kinase Domain
          Length = 316

 Score =  194 bits (492), Expect = 1e-50
 Identities = 90/167 (53%), Positives = 125/167 (74%), Gaps = 1/167 (0%)

Query: 788 EGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847
           E +T  DL+S TYQ+ARGME+LAS+ C+HRDLAARNVL+ +  ++KI DFGLARDI +  
Sbjct: 144 EQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNID 203

Query: 848 NYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYN 907
            Y    +  LPVKWMAPE++FD +YT  SDVWS+G+L+WEIF+LGG+PYPG+ V+  F  
Sbjct: 204 YYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF-K 262

Query: 908 KIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLL 954
            +K G+RM KP + T+E+Y +M  CW++ P +RP+F  L E ++ +L
Sbjct: 263 LLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 309



 Score =  115 bits (289), Expect = 4e-27
 Identities = 57/118 (48%), Positives = 76/118 (64%), Gaps = 2/118 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQP--VMKVAVKMLKPT 632
           V   +LP D +WEFPRD L LG+ LG G FG+VV   A G+ + +P   + VAVKMLK  
Sbjct: 11  VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 70

Query: 633 ARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
           A   +   L+SE+++M  +G H NI+NLLGACT+ GP+Y+I EY   G+L  YL   R
Sbjct: 71  ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 128


>pdb|1FVR|A Chain A, Tie2 Kinase Domain
 pdb|1FVR|B Chain B, Tie2 Kinase Domain
          Length = 327

 Score =  166 bits (419), Expect = 4e-42
 Identities = 85/194 (43%), Positives = 124/194 (63%), Gaps = 6/194 (3%)

Query: 769 KKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ 828
           +K  +L+++    +++  +  L+   LL F   VARGM++L+ K  +HRDLAARN+L+ +
Sbjct: 118 RKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE 177

Query: 829 GKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEI 888
             + KI DFGL+R       YV K    LPV+WMA ES+  ++YTT SDVWSYG+LLWEI
Sbjct: 178 NYVAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEI 234

Query: 889 FSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSE 948
            SLGGTPY GM   +  Y K+  GYR+ KP +   EVY++M +CW  +P +RPSF  +  
Sbjct: 235 VSLGGTPYCGMTC-AELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV 293

Query: 949 IVENLLPGQYKKSY 962
            +  +L  + +K+Y
Sbjct: 294 SLNRML--EERKTY 305



 Score = 65.9 bits (159), Expect = 5e-12
 Identities = 33/93 (35%), Positives = 55/93 (59%), Gaps = 3/93 (3%)

Query: 598 VLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNI 657
           V+G G FG+V++     + +    M  A+K +K  A   + +    EL+++  LG H NI
Sbjct: 32  VIGEGNFGQVLKAR---IKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNI 88

Query: 658 VNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
           +NLLGAC   G +Y+  EY  +G+L+++L K+R
Sbjct: 89  INLLGACEHRGYLYLAIEYAPHGNLLDFLRKSR 121


>pdb|1QCF|A Chain A, Crystal Structure Of Hck In Complex With A Src Family-
           Selective Tyrosine Kinase Inhibitor
          Length = 454

 Score =  150 bits (380), Expect = 1e-37
 Identities = 70/180 (38%), Positives = 110/180 (61%), Gaps = 2/180 (1%)

Query: 773 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 832
           M    + + L  D      L  L+ F+ Q+A GM F+  +N +HRDL A N+L++   + 
Sbjct: 264 MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC 323

Query: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892
           KI DFGLAR ++ D+ Y ++     P+KW APE+I    +T  SDVWS+GILL EI + G
Sbjct: 324 KIADFGLAR-VIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYG 382

Query: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
             PYPGM  +      ++ GYRM +P++   E+Y IM++CW + PE+RP+F ++  ++++
Sbjct: 383 RIPYPGMS-NPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 441


>pdb|1QPE|A Chain A, Structural Analysis Of The Lymphocyte-Specific Kinase Lck
           In Complex With Non-Selective And Src Family Selective
           Kinase Inhibitors
 pdb|1QPJ|A Chain A, Crystal Structure Of The Lymphocyte-Specific Kinase Lck In
           Complex With Staurosporine.
 pdb|1QPC|A Chain A, Structural Analysis Of The Lymphocyte-Specific Kinase Lck
           In Complex With Non-Selective And Src Family Selective
           Kinase Inhibitors
          Length = 279

 Score =  144 bits (364), Expect = 9e-36
 Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 5/190 (2%)

Query: 773 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 832
           M +  + + L   +   LT+  LL    Q+A GM F+  +N +HRDL A N+L++     
Sbjct: 89  MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 148

Query: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892
           KI DFGLAR I  +     +G+ F P+KW APE+I    +T  SDVWS+GILL EI + G
Sbjct: 149 KIADFGLARLIEDNEXTAREGAKF-PIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHG 207

Query: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
             PYPGM       N ++ GYRM +PD+   E+Y++M  CW   PE RP+F +L  ++E+
Sbjct: 208 RIPYPGMTNPEVIQN-LERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 266

Query: 953 LL---PGQYK 959
                 GQY+
Sbjct: 267 FFTATEGQYQ 276


>pdb|1QPD|A Chain A, Structural Analysis Of The Lymphocyte-Specific Kinase Lck
           In Complex With Non-Selective And Src Family Selective
           Kinase Inhibitors
          Length = 279

 Score =  144 bits (364), Expect = 9e-36
 Identities = 75/190 (39%), Positives = 110/190 (57%), Gaps = 5/190 (2%)

Query: 773 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 832
           M +  + + L   +   LT+  LL    Q+A GM F+  +N +HRDL A N+L++     
Sbjct: 89  MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 148

Query: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892
           KI DFGLAR ++ D+   ++     P+KW APE+I    +T  SDVWS+GILL EI + G
Sbjct: 149 KIADFGLAR-LIEDAEXTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHG 207

Query: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
             PYPGM       N ++ GYRM +PD+   E+Y++M  CW   PE RP+F +L  ++E+
Sbjct: 208 RIPYPGMTNPEVIQN-LERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 266

Query: 953 LL---PGQYK 959
                 GQY+
Sbjct: 267 FFTATEGQYQ 276


>pdb|3LCK|  The Kinase Domain Of Human Lymphocyte Kinase (Lck), Activated Form
           (Auto-Phosphorylated On Tyr394)
          Length = 271

 Score =  143 bits (360), Expect = 2e-35
 Identities = 74/180 (41%), Positives = 106/180 (58%), Gaps = 2/180 (1%)

Query: 773 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 832
           M +  + + L   +   LT+  LL    Q+A GM F+  +N +HRDL A N+L++     
Sbjct: 89  MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSC 148

Query: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892
           KI DFGLAR I  +     +G+ F P+KW APE+I    +T  SDVWS+GILL EI + G
Sbjct: 149 KIADFGLARLIEDNEXTAREGAKF-PIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHG 207

Query: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
             PYPGM       N ++ GYRM +PD+   E+Y++M  CW   PE RP+F +L  ++E+
Sbjct: 208 RIPYPGMTNPEVIQN-LERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 266


>pdb|1OPL|A Chain A, Structural Basis For The Auto-Inhibition Of C-Abl Tyrosine
           Kinase
 pdb|1OPL|B Chain B, Structural Basis For The Auto-Inhibition Of C-Abl Tyrosine
           Kinase
          Length = 537

 Score =  142 bits (358), Expect = 4e-35
 Identities = 68/172 (39%), Positives = 104/172 (60%), Gaps = 2/172 (1%)

Query: 782 LSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLAR 841
           L + N + +  + LL    Q++  ME+L  KN +HR+LAARN L+ +  +VK+ DFGL+R
Sbjct: 346 LRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSR 405

Query: 842 DIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMV 901
            +M    Y +      P+KW APES+  N ++  SDVW++G+LLWEI + G +PYPG+ +
Sbjct: 406 -LMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDL 464

Query: 902 DSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENL 953
            S  Y  ++  YRM +P+    +VYE+M  CW   P  RPSF  + +  E +
Sbjct: 465 -SQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETM 515



 Score = 68.6 bits (166), Expect = 8e-13
 Identities = 40/108 (37%), Positives = 58/108 (53%), Gaps = 8/108 (7%)

Query: 581 PYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQA 640
           P   +WE  R  + +   LG G +G+V EG     S     + VAVK LK    + E + 
Sbjct: 249 PNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYS-----LTVAVKTLKED--TMEVEE 301

Query: 641 LMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHK 688
            + E  +M  +  H N+V LLG CT+  P YIITE+  YG+L++YL +
Sbjct: 302 FLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRE 348


>pdb|1FMK|  Crystal Structure Of Human Tyrosine-Protein Kinase C-Src
 pdb|2SRC|  Crystal Structure Of Human Tyrosine-Protein Kinase C-Src, In
           Complex With Amp-Pnp
          Length = 452

 Score =  140 bits (354), Expect = 1e-34
 Identities = 70/212 (33%), Positives = 117/212 (55%), Gaps = 2/212 (0%)

Query: 741 QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTY 800
           Q   ++++    K   +   + + P     + M    + + L  +  + L L  L+    
Sbjct: 228 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 287

Query: 801 QVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVK 860
           Q+A GM ++   N VHRDL A N+L+ +  + K+ DFGLAR ++ D+ Y ++     P+K
Sbjct: 288 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIK 346

Query: 861 WMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDH 920
           W APE+     +T  SDVWS+GILL E+ + G  PYPG MV+    ++++ GYRM  P  
Sbjct: 347 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPE 405

Query: 921 ATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
               ++++M +CW  EPE+RP+F +L   +E+
Sbjct: 406 CPESLHDLMCQCWRKEPEERPTFEYLQAFLED 437


>pdb|1KSW|A Chain A, Structure Of Human C-Src Tyrosine Kinase (Thr338gly
           Mutant) In Complex With N6-Benzyl Adp
          Length = 452

 Score =  140 bits (353), Expect = 2e-34
 Identities = 70/212 (33%), Positives = 117/212 (55%), Gaps = 2/212 (0%)

Query: 741 QYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTY 800
           Q   ++++    K   +   + + P     + M    + + L  +  + L L  L+    
Sbjct: 228 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVGEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 287

Query: 801 QVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVK 860
           Q+A GM ++   N VHRDL A N+L+ +  + K+ DFGLAR ++ D+ Y ++     P+K
Sbjct: 288 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIK 346

Query: 861 WMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDH 920
           W APE+     +T  SDVWS+GILL E+ + G  PYPG MV+    ++++ GYRM  P  
Sbjct: 347 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPE 405

Query: 921 ATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
               ++++M +CW  EPE+RP+F +L   +E+
Sbjct: 406 CPESLHDLMCQCWRKEPEERPTFEYLQAFLED 437


>pdb|1AD5|A Chain A, Src Family Kinase Hck-Amp-Pnp Complex
 pdb|1AD5|B Chain B, Src Family Kinase Hck-Amp-Pnp Complex
 pdb|2HCK|A Chain A, Src Family Kinase Hck-Quercetin Complex
 pdb|2HCK|B Chain B, Src Family Kinase Hck-Quercetin Complex
          Length = 438

 Score =  140 bits (353), Expect = 2e-34
 Identities = 70/180 (38%), Positives = 106/180 (58%), Gaps = 12/180 (6%)

Query: 773 MLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIV 832
           M    + + L  D      L  L+ F+ Q+A GM F+  +N +HRDL A N+L++   + 
Sbjct: 258 MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVC 317

Query: 833 KICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLG 892
           KI DFGLAR           G+ F P+KW APE+I    +T  SDVWS+GILL EI + G
Sbjct: 318 KIADFGLAR----------VGAKF-PIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYG 366

Query: 893 GTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 952
             PYPGM  +      ++ GYRM +P++   E+Y IM++CW + PE+RP+F ++  ++++
Sbjct: 367 RIPYPGMS-NPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDD 425


>pdb|1BYG|A Chain A, Kinase Domain Of Human C-Terminal Src Kinase (Csk) In
           Complex With Inhibitor Staurosporine
          Length = 278

 Score =  140 bits (352), Expect = 2e-34
 Identities = 68/159 (42%), Positives = 99/159 (62%), Gaps = 6/159 (3%)

Query: 795 LLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGS 854
           LL F+  V   ME+L   N VHRDLAARNVL+++  + K+ DFGL ++        ++ +
Sbjct: 119 LLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS-----TQDT 173

Query: 855 TFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR 914
             LPVKW APE++ +  ++T SDVWS+GILLWEI+S G  PYP + +      +++ GY+
Sbjct: 174 GKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDV-VPRVEKGYK 232

Query: 915 MAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENL 953
           M  PD     VYE+M  CW+ +   RPSF  L E +E++
Sbjct: 233 MDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 271


>pdb|1I44|A Chain A, Crystallographic Studies Of An Activation Loop Mutant Of
           The Insulin Receptor Tyrosine Kinase
          Length = 306

 Score =  139 bits (351), Expect = 3e-34
 Identities = 73/175 (41%), Positives = 105/175 (60%), Gaps = 5/175 (2%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           TL +++    ++A GM +L +K  VHRDLAARN ++A    VKI DFG+ RDI   + Y 
Sbjct: 128 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETAYYR 187

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WMAPES+ D ++TT SD+WS+G++LWEI SL   PY G+  +      + 
Sbjct: 188 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 247

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965
            GY + +PD+    V ++M  CW   P+ RP+F    EIV NLL      S+ ++
Sbjct: 248 GGY-LDQPDNCPERVTDLMRMCWQFNPKMRPTFL---EIV-NLLKDDLHPSFPEV 297



 Score = 67.4 bits (163), Expect = 2e-12
 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 2/131 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTAR 634
           V P  +     WE  R+ + L R LG G+FG V EG A  + + +   +VAVK +  +A 
Sbjct: 1   VFPSSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS 60

Query: 635 SSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 694
             E+   ++E  +M     H ++V LLG  +K  P  ++ E   +GDL +YL   R    
Sbjct: 61  LRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE-A 118

Query: 695 SHHPEKPKKEL 705
            ++P +P   L
Sbjct: 119 ENNPGRPPPTL 129


>pdb|1IRK|  Insulin Receptor (Tyrosine Kinase Domain) Mutant With Cys 981
           Replaced By Ser And Tyr 984 Replaced By Phe (C981s,
           Y984f)
          Length = 306

 Score =  139 bits (350), Expect = 4e-34
 Identities = 73/175 (41%), Positives = 104/175 (59%), Gaps = 5/175 (2%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           TL +++    ++A GM +L +K  VHRDLAARN ++A    VKI DFG+ RDI     Y 
Sbjct: 128 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYR 187

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WMAPES+ D ++TT SD+WS+G++LWEI SL   PY G+  +      + 
Sbjct: 188 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 247

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965
            GY + +PD+    V ++M  CW   P+ RP+F    EIV NLL      S+ ++
Sbjct: 248 GGY-LDQPDNCPERVTDLMRMCWQFNPKMRPTFL---EIV-NLLKDDLHPSFPEV 297



 Score = 67.4 bits (163), Expect = 2e-12
 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 2/131 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTAR 634
           V P  +     WE  R+ + L R LG G+FG V EG A  + + +   +VAVK +  +A 
Sbjct: 1   VFPSSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS 60

Query: 635 SSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 694
             E+   ++E  +M     H ++V LLG  +K  P  ++ E   +GDL +YL   R    
Sbjct: 61  LRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE-A 118

Query: 695 SHHPEKPKKEL 705
            ++P +P   L
Sbjct: 119 ENNPGRPPPTL 129


>pdb|1M7N|A Chain A, Crystal Structure Of Unactivated Apo Insulin-Like Growth
           Factor-1 Receptor Kinase Domain
 pdb|1M7N|B Chain B, Crystal Structure Of Unactivated Apo Insulin-Like Growth
           Factor-1 Receptor Kinase Domain
          Length = 322

 Score =  139 bits (349), Expect = 5e-34
 Identities = 70/173 (40%), Positives = 103/173 (59%), Gaps = 2/173 (1%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           +L  ++    ++A GM +L +   VHRDLAARN ++A+   VKI DFG+ RDI     Y 
Sbjct: 136 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 195

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WM+PES+ D ++TT SDVWS+G++LWEI +L   PY G+  +      + 
Sbjct: 196 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL-RFVM 254

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH-LSEIVENLLPGQYKKSY 962
            G  + KPD+    ++E+M  CW   P+ RPSF   +S I E + PG  + S+
Sbjct: 255 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 307



 Score = 71.2 bits (173), Expect = 1e-13
 Identities = 41/127 (32%), Positives = 65/127 (51%), Gaps = 6/127 (4%)

Query: 564 SISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 623
           S++P   EY     + +P    WE  R+ + + R LG G+FG V EG A G+ + +P  +
Sbjct: 3   SVNP---EYFSAADVYVP--DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETR 57

Query: 624 VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLV 683
           VA+K +   A   E+   ++E  +M     H ++V LLG  ++  P  +I E    GDL 
Sbjct: 58  VAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLK 116

Query: 684 NYLHKNR 690
           +YL   R
Sbjct: 117 SYLRSLR 123


>pdb|1JQH|A Chain A, Igf-1 Receptor Kinase Domain
 pdb|1JQH|B Chain B, Igf-1 Receptor Kinase Domain
 pdb|1JQH|C Chain C, Igf-1 Receptor Kinase Domain
          Length = 308

 Score =  139 bits (349), Expect = 5e-34
 Identities = 70/173 (40%), Positives = 103/173 (59%), Gaps = 2/173 (1%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           +L  ++    ++A GM +L +   VHRDLAARN ++A+   VKI DFG+ RDI     Y 
Sbjct: 130 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 189

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WM+PES+ D ++TT SDVWS+G++LWEI +L   PY G+  +      + 
Sbjct: 190 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL-RFVM 248

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH-LSEIVENLLPGQYKKSY 962
            G  + KPD+    ++E+M  CW   P+ RPSF   +S I E + PG  + S+
Sbjct: 249 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 301



 Score = 70.1 bits (170), Expect = 3e-13
 Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 1/105 (0%)

Query: 586 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 645
           WE  R+ + + R LG G+FG V EG A G+ + +P  +VA+K +   A   E+   ++E 
Sbjct: 14  WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA 73

Query: 646 KIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
            +M     H ++V LLG  ++  P  +I E    GDL +YL   R
Sbjct: 74  SVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR 117


>pdb|1P4O|A Chain A, Structure Of Apo Unactivated Igf-1r Kinase Domain At 1.5a
           Resolution.
 pdb|1P4O|B Chain B, Structure Of Apo Unactivated Igf-1r Kinase Domain At 1.5a
           Resolution.
          Length = 322

 Score =  139 bits (349), Expect = 5e-34
 Identities = 70/173 (40%), Positives = 103/173 (59%), Gaps = 2/173 (1%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           +L  ++    ++A GM +L +   VHRDLAARN ++A+   VKI DFG+ RDI     Y 
Sbjct: 136 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYR 195

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WM+PES+ D ++TT SDVWS+G++LWEI +L   PY G+  +      + 
Sbjct: 196 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL-RFVM 254

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH-LSEIVENLLPGQYKKSY 962
            G  + KPD+    ++E+M  CW   P+ RPSF   +S I E + PG  + S+
Sbjct: 255 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 307



 Score = 71.6 bits (174), Expect = 9e-14
 Identities = 41/133 (30%), Positives = 68/133 (51%), Gaps = 6/133 (4%)

Query: 564 SISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMK 623
           S++P   EY     + +P    WE  R+ + + R LG G+FG V EG A G+ + +P  +
Sbjct: 3   SVNP---EYFSAADVYVP--DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETR 57

Query: 624 VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLV 683
           VA+K +   A   E+   ++E  +M     H ++V LLG  ++  P  +I E    GDL 
Sbjct: 58  VAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLK 116

Query: 684 NYLHKNRDSFLSH 696
           +YL   R +  ++
Sbjct: 117 SYLRSLRPAMANN 129


>pdb|1P14|A Chain A, Crystal Structure Of A Catalytic-Loop Mutant Of The
           Insulin Receptor Tyrosine Kinase
          Length = 306

 Score =  137 bits (344), Expect = 2e-33
 Identities = 72/175 (41%), Positives = 103/175 (58%), Gaps = 5/175 (2%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           TL +++    ++A GM +L +K  VHR+LAARN ++A    VKI DFG+ RDI     Y 
Sbjct: 128 TLQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMVAHDFTVKIGDFGMTRDIYETDYYR 187

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WMAPES+ D ++TT SD+WS+G++LWEI SL   PY G+  +      + 
Sbjct: 188 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 247

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965
            GY + +PD+    V ++M  CW   P  RP+F    EIV NLL      S+ ++
Sbjct: 248 GGY-LDQPDNCPERVTDLMRMCWQFNPNMRPTFL---EIV-NLLKDDLHPSFPEV 297



 Score = 67.8 bits (164), Expect = 1e-12
 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 2/131 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTAR 634
           V P  +     WE  R+ + L R LG G+FG V EG A  + + +   +VAVK +  +A 
Sbjct: 1   VFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS 60

Query: 635 SSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 694
             E+   ++E  +M     H ++V LLG  +K  P  ++ E   +GDL +YL   R    
Sbjct: 61  LRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE-A 118

Query: 695 SHHPEKPKKEL 705
            ++P +P   L
Sbjct: 119 ENNPGRPPPTL 129


>pdb|1IR3|A Chain A, Phosphorylated Insulin Receptor Tyrosine Kinase In Complex
           With Peptide Substrate And Atp Analog
 pdb|1GAG|A Chain A, Crystal Structure Of The Insulin Receptor Kinase In
           Complex With A Bisubstrate Inhibitor
          Length = 306

 Score =  136 bits (343), Expect = 2e-33
 Identities = 72/175 (41%), Positives = 103/175 (58%), Gaps = 5/175 (2%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           TL +++    ++A GM +L +K  VHRDLAARN ++A    VKI DFG+ RDI       
Sbjct: 128 TLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIXETDXXR 187

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WMAPES+ D ++TT SD+WS+G++LWEI SL   PY G+  +      + 
Sbjct: 188 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMD 247

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965
            GY + +PD+    V ++M  CW   P+ RP+F    EIV NLL      S+ ++
Sbjct: 248 GGY-LDQPDNCPERVTDLMRMCWQFNPKMRPTFL---EIV-NLLKDDLHPSFPEV 297



 Score = 67.4 bits (163), Expect = 2e-12
 Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 2/131 (1%)

Query: 575 VDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTAR 634
           V P  +     WE  R+ + L R LG G+FG V EG A  + + +   +VAVK +  +A 
Sbjct: 1   VFPSSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESAS 60

Query: 635 SSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFL 694
             E+   ++E  +M     H ++V LLG  +K  P  ++ E   +GDL +YL   R    
Sbjct: 61  LRERIEFLNEASVMKGFTCH-HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPE-A 118

Query: 695 SHHPEKPKKEL 705
            ++P +P   L
Sbjct: 119 ENNPGRPPPTL 129


>pdb|1K3A|A Chain A, Structure Of The Insulin-Like Growth Factor 1 Receptor
           Kinase
          Length = 299

 Score =  134 bits (338), Expect = 9e-33
 Identities = 69/173 (39%), Positives = 101/173 (58%), Gaps = 2/173 (1%)

Query: 791 TLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYV 850
           +L  ++    ++A GM +L +   VHRDLAARN ++A+   VKI DFG+ RDI       
Sbjct: 121 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIXETDXXR 180

Query: 851 SKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIK 910
             G   LPV+WM+PES+ D ++TT SDVWS+G++LWEI +L   PY G+  +      + 
Sbjct: 181 KGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL-RFVM 239

Query: 911 SGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH-LSEIVENLLPGQYKKSY 962
            G  + KPD+    + E+M  CW   P+ RPSF   +S I E + PG  + S+
Sbjct: 240 EGGLLDKPDNCPDMLLELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSF 292



 Score = 70.1 bits (170), Expect = 3e-13
 Identities = 36/105 (34%), Positives = 56/105 (53%), Gaps = 1/105 (0%)

Query: 586 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 645
           WE  R+ + + R LG G+FG V EG A G+ + +P  +VA+K +   A   E+   ++E 
Sbjct: 5   WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEA 64

Query: 646 KIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNR 690
            +M     H ++V LLG  ++  P  +I E    GDL +YL   R
Sbjct: 65  SVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLR 108


>pdb|1M14|A Chain A, Tyrosine Kinase Domain From Epidermal Growth Factor
           Receptor
 pdb|1M17|A Chain A, Epidermal Growth Factor Receptor Tyrosine Kinase Domain
           With 4-Anilinoquinazoline Inhibitor Erlotinib
          Length = 333

 Score =  132 bits (332), Expect = 4e-32
 Identities = 68/153 (44%), Positives = 97/153 (63%), Gaps = 3/153 (1%)

Query: 795 LLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-MHDSNYVSKG 853
           LL++  Q+A+GM +L  +  VHRDLAARNVL+   + VKI DFGLA+ +   +  Y ++G
Sbjct: 125 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 184

Query: 854 STFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGY 913
              +P+KWMA ESI   +YT  SDVWSYG+ +WE+ + G  PY G+   S   + ++ G 
Sbjct: 185 GK-VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPA-SEISSILEKGE 242

Query: 914 RMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHL 946
           R+ +P   T +VY IMVKCW  + + RP F  L
Sbjct: 243 RLPQPPICTIDVYMIMVKCWMIDADSRPKFREL 275


>pdb|1K2P|A Chain A, Crystal Structure Of Bruton's Tyrosine Kinase Domain
 pdb|1K2P|B Chain B, Crystal Structure Of Bruton's Tyrosine Kinase Domain
          Length = 263

 Score =  125 bits (315), Expect = 4e-30
 Identities = 62/149 (41%), Positives = 92/149 (61%), Gaps = 2/149 (1%)

Query: 795 LLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGS 854
           LL     V   ME+L SK  +HRDLAARN L+    +VK+ DFGL+R ++ D    S GS
Sbjct: 102 LLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGS 161

Query: 855 TFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR 914
            F PV+W  PE +  + +++ SD+W++G+L+WEI+SLG  PY     +S     I  G R
Sbjct: 162 KF-PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYE-RFTNSETAEHIAQGLR 219

Query: 915 MAKPDHATSEVYEIMVKCWNSEPEKRPSF 943
           + +P  A+ +VY IM  CW+ + ++RP+F
Sbjct: 220 LYRPHLASEKVYTIMYSCWHEKADERPTF 248



 Score = 63.5 bits (153), Expect = 3e-11
 Identities = 44/105 (41%), Positives = 59/105 (56%), Gaps = 10/105 (9%)

Query: 589 PRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIM 648
           P+D L   + LG+G FG V     YG  R Q    VA+KM+K  + S ++   + E K+M
Sbjct: 3   PKD-LTFLKELGTGQFGVV----KYGKWRGQ--YDVAIKMIKEGSMSEDE--FIEEAKVM 53

Query: 649 THLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSF 693
            +L  H  +V L G CTK  PI+IITEY   G L+NYL + R  F
Sbjct: 54  MNLS-HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF 97


>pdb|1PME|  Structure Of Penta Mutant Human Erk2 Map Kinase Complexed With A
           Specific Inhibitor Of Human P38 Map Kinase
          Length = 380

 Score = 68.9 bits (167), Expect = 6e-13
 Identities = 37/95 (38%), Positives = 57/95 (60%), Gaps = 2/95 (2%)

Query: 798 FTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFL 857
           F YQ+ RG++++ S N +HRDL   N+LL     +KICDFGLAR    D ++    + ++
Sbjct: 149 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTXDLKICDFGLARVADPDHDHTGFLTEYV 208

Query: 858 PVKW-MAPESIFDNL-YTTLSDVWSYGILLWEIFS 890
             +W  APE + ++  YT   D+WS G +L E+ S
Sbjct: 209 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 243


>pdb|1JOW|B Chain B, Crystal Structure Of A Complex Of Human Cdk6 And A Viral
           Cyclin
          Length = 308

 Score = 64.3 bits (155), Expect = 1e-11
 Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 3/116 (2%)

Query: 774 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 833
           +D ++   L      G+    +    +Q+ RG++FL S   VHRDL  +N+L+     +K
Sbjct: 101 VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK 160

Query: 834 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 889
           + DFGLAR     S  ++  S  + + + APE +  + Y T  D+WS G +  E+F
Sbjct: 161 LADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213


>pdb|1BI8|A Chain A, Mechanism Of G1 Cyclin Dependent Kinase Inhibition From
           The Structures Cdk6-P19ink4d Inhibitor Complex
 pdb|1BI8|C Chain C, Mechanism Of G1 Cyclin Dependent Kinase Inhibition From
           The Structures Cdk6-P19ink4d Inhibitor Complex
 pdb|1BI7|A Chain A, Mechanism Of G1 Cyclin Dependent Kinase Inhibition From
           The Structure Of The Cdk6-P16ink4a Tumor Suppressor
           Complex
 pdb|1BLX|A Chain A, P19ink4dCDK6 COMPLEX
 pdb|1G3N|A Chain A, Structure Of A P18(Ink4c)-Cdk6-K-Cyclin Ternary Complex
 pdb|1G3N|E Chain E, Structure Of A P18(Ink4c)-Cdk6-K-Cyclin Ternary Complex
          Length = 326

 Score = 64.3 bits (155), Expect = 1e-11
 Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 3/116 (2%)

Query: 774 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 833
           +D ++   L      G+    +    +Q+ RG++FL S   VHRDL  +N+L+     +K
Sbjct: 101 VDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIK 160

Query: 834 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 889
           + DFGLAR     S  ++  S  + + + APE +  + Y T  D+WS G +  E+F
Sbjct: 161 LADFGLARIY---SFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMF 213


>pdb|1F3M|C Chain C, Crystal Structure Of Human SerineTHREONINE KINASE PAK1
 pdb|1F3M|D Chain D, Crystal Structure Of Human SerineTHREONINE KINASE PAK1
          Length = 297

 Score = 62.4 bits (150), Expect = 6e-11
 Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 6/141 (4%)

Query: 804 RGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVK-WM 862
           + +EFL S   +HRD+ + N+LL     VK+ DFG    I  +    SK ST +    WM
Sbjct: 127 QALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQ---SKRSTMVGTPYWM 183

Query: 863 APESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGY-RMAKPDHA 921
           APE +    Y    D+WS GI+  E+   G  PY         Y    +G   +  P+  
Sbjct: 184 APEVVTRKAYGPKVDIWSLGIMAIEMIE-GEPPYLNENPLRALYLIATNGTPELQNPEKL 242

Query: 922 TSEVYEIMVKCWNSEPEKRPS 942
           ++   + + +C + + EKR S
Sbjct: 243 SAIFRDFLNRCLDMDVEKRGS 263


  Database: PDB protein database
    Posted date:  Oct 8, 2003 12:18 AM
  Number of letters in database: 10,828,398
  Number of sequences in database:  45,671
  
Lambda     K      H
   0.316    0.134    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 302,130
Number of Sequences: 45671
Number of extensions: 13264
Number of successful extensions: 86
Number of sequences better than 1.0e-10: 8
Number of HSP's better than  0.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 54
Number of HSP's gapped (non-prelim): 17
length of query: 1089
length of database: 623,310
effective HSP length: 87
effective length of query: 1002
effective length of database: 336,558
effective search space: 337231116
effective search space used: 337231116
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 148 (61.6 bits)